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Structures and general transport mechanisms by the major facilitator superfamily (MFS)
The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …
transporters. MFS transporters are responsible for transporting a broad spectrum of …
[HTML][HTML] The concept of folic acid in health and disease
Y Shulpekova, V Nechaev, S Kardasheva, A Sedova… - Molecules, 2021 - mdpi.com
Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …
A broad-spectrum antibiotic adjuvant reverses multidrug-resistant Gram-negative pathogens
The rapid emergence and dissemination of multidrug-resistant (MDR) bacterial pathogens
pose a serious threat to global healthcare. One particular concern is the carbapenem …
pose a serious threat to global healthcare. One particular concern is the carbapenem …
Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria
Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …
organisms are diverse in function, energization, and structural organization. They form …
Organic cation transporters in health and disease
H Koepsell - Pharmacological reviews, 2020 - Elsevier
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
A call for systematic research on solute carriers
Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …
The SLC2 (GLUT) family of membrane transporters
GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator
superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human …
superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human …
Understanding transport by the major facilitator superfamily (MFS): structures pave the way
EM Quistgaard, C Löw, F Guettou… - Nature Reviews Molecular …, 2016 - nature.com
Members of the major facilitator superfamily (MFS) of transport proteins are essential for the
movement of a wide range of substrates across biomembranes. As this transport requires a …
movement of a wide range of substrates across biomembranes. As this transport requires a …
Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis
How phosphate levels are detected in mammals is unknown. The bone-derived hormone
fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney …
fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney …
Shared molecular mechanisms of membrane transporters
The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …
the conformational changes that take place during structural isomerization from outward-to …