Impaired cellular homeostasis of metals, particularly of Cu, Fe and Mn may trigger
neurodegeneration through various mechanisms, notably induction of oxidative stress …

The direct detection of biologically relevant metals in single cells and of their speciation is a
challenging task that requires sophisticated analytical developments. The aim of this article …

Metal ions are known to play an important role in many neurodegenerative diseases
including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis …

A variety of Magnetic Resonance Imaging (MRI) techniques are known to be sensitive to
brain iron content. In principle, iron sensitive MRI techniques are based on local magnetic …

This early career research highlight provides a review of my own research program over the
last decade, a time frame that encompasses my transition from postdoctoral fellowships to …

Stroke is a major global health problem, with the prevalence and economic burden
predicted to increase due to aging populations in western society. Following stroke …

Identification of chemical species at a subcellular level is a key to understand the
mechanisms involved in the biology of chemical elements. When performed with a …

A unique combination of sensitivity, resolution, and penetration make X-ray fluorescence
imaging (XFI) ideally suited to investigate trace elemental distributions in the biological …

Dysregulation of localized iron homeostasis is implicated in several degenerative diseases,
including Parkinson's, Alzheimer's, and age-related macular degeneration, wherein iron …

There is evidence for iron dysregulation in many forms of disease, including a broad
spectrum of neurodegenerative disorders. In order to advance our understanding of the …