Bipolar disorder is a multifactorial illness with uncertain aetiology. Knowledge of potential
risk factors enables clinicians to identify patients who are more likely to develop bipolar …

Objectives: Despite the demonstrated high heritability of bipolar disorder, few susceptibility
genes have been identified and linkage and/or association studies have produced …

Objective: Duration of untreated illness represents a potentially modifiable component of any
diagnosis‐treatment pathway. In bipolar disorder (BD), this concept has rarely been …

Importance Early identification of individuals at high risk for the onset of bipolar spectrum
disorder (BPSD) is key from both a clinical and research perspective. While previous work …

Objectives To identify clinical characteristics and adverse outcomes associated with an
earlier age of onset of bipolar disorder. Methods A comprehensive search yielded 15 …

Early onset in bipolar disorder (BPD) has been associated with greater familial risk and
unfavorable clinical outcomes. We pooled data from seven international centers to analyze …

Childhood trauma has been suggested to be involved in the susceptibility to bipolar
disorder. However, case-control studies are lacking, and the preferential implication and the …

Objective Bipolar disorder (BD) is a chronic mental health disorder with significant morbidity
and mortality. Age at onset (AAO) may be a key variable in delineating more homogeneous …

Objective: The long-term course of bipolar disorder is typified by recurring mood episodes of
opposite polarity as well as mixed states. Rapid-cycling bipolar disorder refers to the …

Rapid-cycling in bipolar disorder (RC-BD) is associated with greater illness morbidity and
inferior treatment response but many aspects remain unclear, prompting this systematic …