Differentiation of effector CD4 T cell populations
CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …
[HTML][HTML] The canonical Notch signaling pathway: unfolding the activation mechanism
R Kopan, MXG Ilagan - Cell, 2009 - cell.com
Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …
The differential expression of IL-4 and IL-13 and its impact on type-2 immunity
K Bao, RL Reinhardt - Cytokine, 2015 - Elsevier
Allergic disease represents a significant global health burden, and disease incidence
continues to rise in urban areas of the world. As such, a better understanding of the basic …
continues to rise in urban areas of the world. As such, a better understanding of the basic …
Canonical and non-canonical Notch ligands
B D'Souza, L Meloty-Kapella, G Weinmaster - Current topics in …, 2010 - Elsevier
Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions …
development and tissue homeostasis through the regulation of a variety of cell fate decisions …
Early signaling events that underlie fate decisions of naive CD4+ T cells toward distinct T‐helper cell subsets
H Yamane, WE Paul - Immunological reviews, 2013 - Wiley Online Library
Summary CD 4+ T‐helper (Th) cells are a major cell population that play an important role in
governing acquired immune responses to a variety of foreign antigens as well as inducing …
governing acquired immune responses to a variety of foreign antigens as well as inducing …
Role of Notch signaling in regulating innate immunity and inflammation in health and disease
The Notch signaling pathway is conserved from Drosophila to mammals and is critically
involved in developmental processes. In the immune system, it has been established that …
involved in developmental processes. In the immune system, it has been established that …
[HTML][HTML] GATA-3 function in innate and adaptive immunity
I Tindemans, N Serafini, JP Di Santo, RW Hendriks - Immunity, 2014 - cell.com
The zinc-finger transcription factor GATA-3 has received much attention as a master
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …
Notch in T cell differentiation: all things considered
D Amsen, C Helbig, RA Backer - Trends in immunology, 2015 - cell.com
Differentiation of naïve T cells into effector cells is required for optimal protection against
different classes of microbial pathogen and for the development of immune memory. Recent …
different classes of microbial pathogen and for the development of immune memory. Recent …
Notch signal strength controls cell fate in the haemogenic endothelium
L Gama-Norton, E Ferrando, C Ruiz-Herguido… - Nature …, 2015 - nature.com
Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta–
gonad–mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The …
gonad–mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The …
[HTML][HTML] Do as I say, Not (ch) as I do: Lateral control of cell fate
M Sjöqvist, ER Andersson - Developmental biology, 2019 - Elsevier
Breaking symmetry in populations of uniform cells, to induce adoption of an alternative cell
fate, is an essential developmental mechanism. Similarly, domain and boundary …
fate, is an essential developmental mechanism. Similarly, domain and boundary …