Advanced liver disease presents a significant worldwide health and economic burden and
accounts for 3.5% of global mortality. When liver disease progresses to organ failure the …

Bioengineered livers are promising in vitro models for drug testing, toxicological studies, and
as disease models, and might in the future be an alternative for donor organs to treat end …

Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular
network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary …

The field of tissue engineering (TE) has made tremendous progress in the past decade and
is still evolving. It is not only now possible to control cells and their environments more …

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein, which is
frequently and highly expressed on carcinomas, tumor-initiating cells, selected tissue …

Wholly defined ex vivo expansion conditions for biliary tree stem cell (BTSC) organoids were
established, consisting of a defined proliferative medium (DPM) used in combination with …

Orthotopic liver transplantation remains the only curative treatment for liver disease.
However, the number of patients who die while on the waiting list (15%) has increased in …

Chronic liver disease and cirrhosis is a widespread and untreatable condition that leads to
lifelong impairment and eventual death. The scarcity of liver transplantation options requires …

Regenerative medicine is transitioning into clinical programs using stem/progenitor cell
therapies for repair of damaged organs. We summarize those for liver and pancreas, organs …

Niches containing stem/progenitor cells are present in different anatomical locations along
the human biliary tree and within liver acini. The most primitive stem/progenitors, biliary tree …