Since ancient times it is known that melancholia and sleep disturbances co-occur. The
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …

Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Abstract Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem,
zopiclone, and zaleplon) are FDA-approved for insomnia disorders with a strong evidence …

The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal
function. Altered TRP metabolism has been implicated in the pathophysiology of various …

Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …

Melatonin, mostly released by the pineal gland, is a circadian rhythm-regulated and
multifunctional hormone. Great advances in melatonin research have been made, including …

Identifying the target cells of a hormone is a key step in understanding its function. Once the
molecular nature of the receptors for a hormone has been established, researchers can use …

Anxiety disorders are the most common mental diseases. Anxiety and the associated
physical symptoms may disturb social and occupational life and increase the risk of somatic …

Melatonin is a naturally occurring molecule secreted by the pineal gland and known as a
gatekeeper of circadian clocks. Mounting evidence indicates that melatonin, employing …

Melatonin is a ubiquitous hormone found in various organisms and highly affects the
function of immune cells. In this review, we summarize the current understanding of the …