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RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors
C Arter, L Trask, S Ward, S Yeoh, R Bayliss - Journal of Biological Chemistry, 2022 - jbc.org
Protein kinases are key components in cellular signaling pathways as they carry out the
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …
BI-3406, a potent and selective SOS1–KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition
MH Hofmann, M Gmachl, J Ramharter… - Cancer …, 2021 - aacrjournals.org
KRAS is the most frequently mutated driver of pancreatic, colorectal, and non–small cell lung
cancers. Direct KRAS blockade has proved challenging, and inhibition of a key downstream …
cancers. Direct KRAS blockade has proved challenging, and inhibition of a key downstream …
Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression
Mitogen-activated protein kinase (MAPK) signal transduction, as a highly conserved
signaling pathway, is reported to be involved in various biological events, including …
signaling pathway, is reported to be involved in various biological events, including …
[HTML][HTML] Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy
The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAF-MEK-
ERK signal cascade, functions to transmit upstream signals to its downstream effectors to …
ERK signal cascade, functions to transmit upstream signals to its downstream effectors to …
Negative feedback regulation of the ERK1/2 MAPK pathway
D Lake, SAL Corrêa, J Müller - Cellular and Molecular Life Sciences, 2016 - Springer
The extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase
(MAPK) signalling pathway regulates many cellular functions, including proliferation …
(MAPK) signalling pathway regulates many cellular functions, including proliferation …
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road
The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours
in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive …
in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive …
Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy
L Santarpia, SM Lippman… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: The MAPK pathway comprises several key signaling components and
phosphorylation events that play a role in tumorigenesis. These activated kinases transmit …
phosphorylation events that play a role in tumorigenesis. These activated kinases transmit …
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis
A Latourte, C Cherifi, J Maillet, HK Ea… - Annals of the …, 2017 - ard.bmj.com
Objective To investigate the impact of systemic inhibition of interleukin 6 (IL-6) or signal
transducer and activator of transcription (Stat3) in an experimental model of osteoarthritis …
transducer and activator of transcription (Stat3) in an experimental model of osteoarthritis …