Device-based solutions to improve cardiac physiology and hemodynamics in heart failure with preserved ejection fraction

L Rosalia, C Ozturk, S Shoar, Y Fan, G Malone… - Basic to Translational …, 2021 - jacc.org
Characterized by a rapidly increasing prevalence, elevated mortality and rehospitalization
rates, and inadequacy of pharmaceutical therapies, heart failure with preserved ejection …

The Future of Durable Mechanical Circulatory Support–Emerging Technological Innovations and Considerations to Enable Evolution of the Field

SA Dual, J Cowger, E Roche, A Nayak - Journal of cardiac failure, 2024 - Elsevier
The field of durable mechanical circulatory support (MCS) has undergone an incredible
evolution over the past few decades, resulting in significant improvements in longevity and …

Soft robotic patient-specific hydrodynamic model of aortic stenosis and ventricular remodeling

L Rosalia, C Ozturk, D Goswami, J Bonnemain… - Science robotics, 2023 - science.org
Aortic stenosis (AS) affects about 1.5 million people in the United States and is associated
with a 5-year survival rate of 20% if untreated. In these patients, aortic valve replacement is …

Modulating cardiac hemodynamics using tunable soft robotic sleeves in a porcine model of hfpef physiology for device testing applications

L Rosalia, C Ozturk, SX Wang… - Advanced Functional …, 2024 - Wiley Online Library
Heart failure with preserved ejection fraction (HFpEF) is a major challenge in cardiovascular
medicine, accounting for≈ 50% of all cases of heart failure. Despite the ongoing efforts, no …

Device-based treatment options for heart failure with preserved ejection fraction

C Miyagi, T Miyamoto, JH Karimov, RC Starling… - Heart failure …, 2021 - Springer
Heart failure with preserved ejection fraction (HFpEF) is a syndrome with an unfavorable
prognosis, and the number of the patients continues to grow. Because there is no effective …

Can mechanical circulatory support be an effective treatment for HFpEF patients?

E Gude, AE Fiane - Heart Failure Reviews, 2023 - Springer
Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence and
represents approximately 50% of all heart failure (HF) patients. Patients with this complex …

Left atrial assist device for heart failure with preserved ejection fraction: initial results with torque control mode in diastolic heart failure model

C Miyagi, BD Kuban, CR Flick, AR Polakowski… - Heart Failure …, 2023 - Springer
A novel pump, the left atrial assist device (LAAD), is a device specifically for the treatment of
heart failure with preserved ejection fraction (HFpEF). The LAAD is a mixed-flow pump that …

Comparison of device-based therapy options for heart failure with preserved ejection fraction: a simulation study

M Granegger, C Gross, D Siemer, A Escher… - Scientific Reports, 2022 - nature.com
Successful therapy of heart failure with preserved ejection fraction (HFpEF) remains a major
unmet clinical need. Device-based treatment approaches include the interatrial shunt device …

Large animal models of heart failure with preserved ejection fraction

C Miyagi, T Miyamoto, T Kuroda, JH Karimov… - Heart failure …, 2022 - Springer
Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic
dysfunction and multiple comorbidities. The number of patients is continuously increasing …

A numerical study of a left ventricular expander for heart failure with preserved ejection fraction

J Weissmann, YC Benoliel… - Royal Society Open …, 2023 - royalsocietypublishing.org
Increased cardiac stiffness hinders proper left ventricular (LV) expansion, resulting in
decreased volume and diastolic dysfunction. LV expanders are spring-like devices designed …