The three subsets of human monocytes, classical, intermediate, and nonclassical, show
phenotypic heterogeneity, particularly in their expression of CD14 and CD16. This has …

Effective responses against severe systemic infection require coordination between two
complementary defense strategies that minimize the negative impact of infection on the host …

Most animals require sleep, and sleep loss induces serious pathophysiological
consequences, including death. Previous experimental approaches for investigating sleep …

Classical monocytes (CMs) are ephemeral myeloid immune cells that circulate in the blood.
Emerging evidence suggests that CMs can have distinct ontogeny and originate from either …

Intermittent fasting (IF) modifies cell-and tissue-specific immunometabolic responses that
dictate metabolic flexibility and inflammation during obesity and type 2 diabetes (T2D) …

Microplastics (MPs) have gained significant attention due to their widespread presence in
the environment. While studies have been conducted to investigate the risks associated with …

Exercise, stress, sleep and diet are four distinct but intertwined lifestyle factors that influence
the cardiovascular system. Abundant epidemiological, clinical and preclinical studies have …

Dietary fasting markedly influences the distribution and function of immune cells and exerts
potent immunosuppressive effects. However, the mechanisms through which fasting …

As the global population ages, the prevalence of neurodegenerative diseases is surging.
These disorders have a multifaceted pathogenesis, entwined with genetic and …

While it is well known that 98–99% of the human genome does not encode proteins, but are
nevertheless transcriptionally active and give rise to a broad spectrum of noncoding RNAs …