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Current mouse and cell models in prostate cancer research
X Wu, S Gong, P Roy-Burman, P Lee… - Endocrine-related …, 2013 - erc.bioscientifica.com
Mouse models of prostate cancer (PCa) are critical for understanding the biology of PCa
initiation, progression, and treatment modalities. Here, we summarize recent advances in …
initiation, progression, and treatment modalities. Here, we summarize recent advances in …
Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome
Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by
developmental delay, impaired communication, motor deficits and ataxia, intellectual …
developmental delay, impaired communication, motor deficits and ataxia, intellectual …
Predicting response to hormonal therapy and survival in men with hormone sensitive metastatic prostate cancer
PD Grivas, DM Robins, M Hussain - Critical reviews in oncology …, 2013 - Elsevier
Androgen deprivation is the cornerstone of the management of metastatic prostate cancer.
Despite several decades of clinical experience with this therapy there are no standard …
Despite several decades of clinical experience with this therapy there are no standard …
Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy
JP Chua, SL Reddy, DE Merry, H Adachi… - Human molecular …, 2014 - academic.oup.com
Spinobulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by
the expansion of a CAG repeat encoding a polyglutamine tract in exon 1 of the androgen …
the expansion of a CAG repeat encoding a polyglutamine tract in exon 1 of the androgen …
Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy
Spinal bulbar muscular atrophy (SBMA) is a motor neuron disease caused by toxic gain of
function of the androgen receptor (AR). Previously, we found that co-regulator binding …
function of the androgen receptor (AR). Previously, we found that co-regulator binding …
Length of the human androgen receptor glutamine tract determines androgen sensitivity in vivo
U Simanainen, M Brogley, YR Gao, M Jimenez… - Molecular and cellular …, 2011 - Elsevier
A well established functional polymorphism of the human androgen receptor (hAR) is the
length of AR's N-terminal glutamine tract (Q-tract). This tract is encoded by a CAG …
length of AR's N-terminal glutamine tract (Q-tract). This tract is encoded by a CAG …
Interaction of the androgen receptor, ETV1, and PTEN pathways in mouse prostate varies with pathological stage and predicts cancer progression
J Higgins, M Brogley, N Palanisamy, R Mehra… - Hormones and …, 2015 - Springer
To examine the impact of common somatic mutations in prostate cancer (PCa) on androgen
receptor (AR) signaling, mouse models were designed to perturb sequentially the AR, ETV1 …
receptor (AR) signaling, mouse models were designed to perturb sequentially the AR, ETV1 …
Spatial gene expression analysis of neuroanatomical differences in mouse models
MRI is a powerful modality to detect neuroanatomical differences that result from mutations
and treatments. Knowing which genes drive these differences is important in understanding …
and treatments. Knowing which genes drive these differences is important in understanding …
Contribution of the unfolded protein response to breast and prostate tissue homeostasis and its significance to cancer endocrine response
I Direito, M Fardilha, LA Helguero - Carcinogenesis, 2019 - academic.oup.com
Resistant breast and prostate cancers remain a major clinical problem, new therapeutic
approaches and better predictors of therapeutic response are clearly needed. Because of …
approaches and better predictors of therapeutic response are clearly needed. Because of …
Corepressor effect on androgen receptor activity varies with the length of the CAG encoded polyglutamine repeat and is dependent on receptor/corepressor ratio in …
G Buchanan, EF Need, JM Barrett… - Molecular and cellular …, 2011 - Elsevier
The response of prostate cells to androgens reflects a combination of androgen receptor
(AR) transactivation and transrepression, but how these two processes differ mechanistically …
(AR) transactivation and transrepression, but how these two processes differ mechanistically …