The intricate balance of immune reactions towards invading pathogens and immune
tolerance towards self is pivotal in preventing autoimmune diseases, with the thymus playing …

Dysregulation of the immune system is associated with many pathologies, including
cardiovascular diseases, diabetes, and cancer. To date, the most commonly used models in …

The thymus is the primary organ responsible for generating functional T cells in vertebrates.
Although T cell differentiation within the thymus has been an area of intense investigation …

The generation of a peripheral T-cell pool is essential for normal immune system function.
CD4+ and CD8+ T cells are produced most efficiently in the thymus, which provides a …

Thymocytes depend on the interaction with thymic epithelial cells for the generation of a
diverse, nonautoreactive T cell repertoire. In turn, thymic epithelial cells acquire their three …

T cell differentiation and repertoire selection depend critically on several distinct thymic
epithelial cell types, whose lineage relationships are unclear. We have investigated these …

T cell differentiation in the thymus depends on sequential interactions between lymphoid
progenitors and stromal cells in discrete regions of the cortex. Here we show that …

T cell development is tightly controlled by thymic stromal cells. Alterations in stromal
architecture affect T cell maturation and the development of self-tolerance. The monogenic …

In some respects, our understanding of the cellular and molecular aspects of early T-cell
differentiation is lagging behind that of B cells. Papers describing gene-knockout and …

The autoimmune regulator Aire is expressed in a small proportion of medullary thymic
epithelial cells (mTECs) and is crucial in the induction of central T cell tolerance. The origin …