Substantial research over the past two decades has established that extracellular matrix
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …

All cells sense and integrate mechanical and biochemical cues from their environment to
orchestrate organismal development and maintain tissue homeostasis …

Cortical neurons and astrocytes respond strongly to changes in matrix rigidity when cultured
on flexible substrates. In this study, existing polyacrylamide gel polymerization methods …

This paper contains experimental results of in vitro, uniaxial tension of swine brain tissue in
finite deformation as well as proposes a new hyper-viscoelastic constitutive model for the …

One hundred fifty years ago glial cells were discovered as a second, non-neuronal, cell type
in the central nervous system. To ascribe a function to these new, enigmatic cells, it was …

Realistic computer simulation of neurosurgical procedures requires incorporation of the
mechanical properties of brain tissue in the mathematical model. Possible applications of …

The objective of this study was to investigate potential for traumatic brain injuries (TBI) using
a newly developed, geometrically detailed, finite element head model (FEHM) within the …

The purpose of this study was to obtain normative data using magnetic resonance
elastography (MRE)(a) to obtain estimates of the shear modulus of human cerebral tissue in …

Beginning in the 1960s many studies have been performed to investigate the mechanical
properties of brain. In this paper we point out the difficulties linked with in vitro experimental …

Slow, large deformations of human brain tissue—accompanying cranial vault deformation
induced by positional plagiocephaly, occurring during hydrocephalus, and in the …