Role of platelet mitochondria: life in a nucleus-free zone
Platelets are abundant, small, anucleate circulating cells, serving many emerging
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis …
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis …
Platelet extracellular vesicles and the secretory interactome join forces in health and disease
E Boilard, M Bellio - Immunological Reviews, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are small membrane‐bound vesicles released by cells under
various conditions. They are found in the extracellular milieu in all biological fluids. As the …
various conditions. They are found in the extracellular milieu in all biological fluids. As the …
Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis
(conversion of glucose to lactate in the presence of oxygen) for their energy requirements. In …
(conversion of glucose to lactate in the presence of oxygen) for their energy requirements. In …
[HTML][HTML] Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches
JF Hebert, L Myatt - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2021 - Elsevier
Both obesity and gestational diabetes mellitus (GDM) lead to poor maternal and fetal
outcomes, including pregnancy complications, fetal growth issues, stillbirth, and …
outcomes, including pregnancy complications, fetal growth issues, stillbirth, and …
Energy metabolism in platelets fuels thrombus formation: halting the thrombosis engine with small-molecule modulators of platelet metabolism
Platelets are circulating cells central to haemostasis that follows vessel injury, as well as
thrombosis that ensues as a consequence of pathological stasis or plaque rupture. Platelet …
thrombosis that ensues as a consequence of pathological stasis or plaque rupture. Platelet …
Fatty acid oxidation fuels agonist‐induced platelet activation and thrombus formation: targeting β‐oxidation of fatty acids as an effective anti‐platelet strategy
Platelet mitochondria possess remarkable plasticity for oxidation of energy substrates,
where metabolic dependency on glucose or fatty acids is higher than glutamine. Since …
where metabolic dependency on glucose or fatty acids is higher than glutamine. Since …
Platelet mitochondria: the mighty few
Platelet mitochondria: the mighty few : Current Opinion in Hematology Platelet mitochondria: the
mighty few : Current Opinion in Hematology Log in or Register Subscribe to journalSubscribe …
mighty few : Current Opinion in Hematology Log in or Register Subscribe to journalSubscribe …
[HTML][HTML] Blood-based bioenergetics: a liquid biopsy of mitochondrial dysfunction in disease
MS Wilkinson, KJ Dunham-Snary - Trends in Endocrinology & Metabolism, 2023 - cell.com
Mitochondria operate as hubs of cellular metabolism that execute important regulatory
functions. Damaged/dysfunctional mitochondria are recognized as major pathogenic …
functions. Damaged/dysfunctional mitochondria are recognized as major pathogenic …
Mitochondria transfer by platelet-derived microparticles regulates breast cancer bioenergetic states and malignant features
V Veilleux, N Pichaud, LH Boudreau… - Molecular Cancer …, 2024 - AACR
An increasing number of studies show that platelets as well as platelet-derived
microparticles (PMP) play significant roles in cancer malignancy and disease progression …
microparticles (PMP) play significant roles in cancer malignancy and disease progression …
Metabolic targeting of platelets to combat thrombosis: dawn of a new paradigm?
Current antithrombotic therapies used in clinical settings target either the coagulation
pathways or platelet activation receptors (P2Y12 or GPIIb/IIIa), as well as the …
pathways or platelet activation receptors (P2Y12 or GPIIb/IIIa), as well as the …