Microenvironment-responsive drug delivery systems (DDSs) can achieve targeted drug
delivery, reduce drug side effects and improve drug efficacies. Among them, pH-responsive …

Drug delivery to central nervous system (CNS) diseases is very challenging since the
presence of the innate blood–brain barrier (BBB) and the blood-cerebrospinal fluid barrier …

Stroke is a primary cause of death and disability worldwide, while effective and safe drugs
remain to be developed for its clinical treatment. Herein, we report bioactive nanoparticle …

Inflammation is intimately related to the pathogenesis of numerous acute and chronic
diseases like cardiovascular disease, inflammatory bowel disease, rheumatoid arthritis, and …

Ischemic stroke is an acute and serious cerebral vascular disease, which greatly affects
people's health and brings huge economic burden to society. Microglia, as important innate …

Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …

Aging-induced alternations of vasculature structures, phenotypes, and functions are key in
the occurrence and development of vascular aging-related diseases. Multiple molecular and …

Rational design of nanomedicine to accelerate thrombolysis and sequentially avoid
thrombolysis-mediated reperfusion injury is still a challenge. Here, we develop a biomimetic …

Thrombotic cardio‐cerebrovascular diseases seriously threaten human health. Currently,
conventional thrombolytic treatments are challenged by the low utilization, inferior thrombus …

Ischemic stroke leads to high disability and mortality. The limited delivery efficiency of most
therapeutic substances is a major challenge for effective treatment of ischemic stroke …