Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems

B Koskella, CA Hernandez… - Annual Review of …, 2022 - annualreviews.org
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …

Pharmacological limitations of phage therapy

AS Nilsson - Upsala journal of medical sciences, 2019 - Taylor & Francis
Clinical trial results of phage treatment of bacterial infections show a low to moderate
efficacy, and the variation in infection clearance between subjects within studies is often …

The spatial heterogeneity of the gut limits predation and fosters coexistence of bacteria and bacteriophages

M Lourenço, L Chaffringeon, Q Lamy-Besnier… - Cell Host & Microbe, 2020 - cell.com
The ecological dynamics underlying the coexistence between antagonistic populations of
bacteria and their viruses, bacteriophages (phages), in the mammalian gut microbiota …

Coevolutionary phage training leads to greater bacterial suppression and delays the evolution of phage resistance

JM Borin, S Avrani, JE Barrick, KL Petrie… - Proceedings of the …, 2021 - pnas.org
The evolution of antibiotic-resistant bacteria threatens to become the leading cause of
worldwide mortality. This crisis has renewed interest in the practice of phage therapy. Yet …

Multistep diversification in spatiotemporal bacterial-phage coevolution

E Shaer Tamar, R Kishony - Nature Communications, 2022 - nature.com
The evolutionary arms race between phages and bacteria, where bacteria evolve resistance
to phages and phages retaliate with resistance-countering mutations, is a major driving force …

Resistance evolution against phage combinations depends on the timing and order of exposure

RCT Wright, VP Friman, MCM Smith, MA Brockhurst - MBio, 2019 - journals.asm.org
Phage therapy is a promising alternative to chemotherapeutic antibiotics for the treatment of
bacterial infections. However, despite recent clinical uses of combinations of phages to treat …

Bacteriophage production models: an overview

R García, S Latz, J Romero, G Higuera… - Frontiers in …, 2019 - frontiersin.org
The use of bacteriophages has been proposed as an alternative method to control
pathogenic bacteria. During recent years several reports have been published about the …

[HTML][HTML] The gut environment regulates bacterial gene expression which modulates susceptibility to bacteriophage infection

M Lourenço, L Chaffringeon, Q Lamy-Besnier… - Cell Host & Microbe, 2022 - cell.com
Abundance and diversity of bacteria and their viral predators, bacteriophages (phages), in
the digestive tract are associated with human health. Particularly intriguing is the long-term …

Manufacturing of bacteriophages for therapeutic applications

J João, J Lampreia, DMF Prazeres, AM Azevedo - Biotechnology Advances, 2021 - Elsevier
Bacteriophages, or simply phages, are the most abundant biological entities on Earth. One
of the most interesting characteristics of these viruses, which infect and use bacteria as their …

The never-ending battle between lactic acid bacteria and their phages

C Philippe, JK Cornuault, AG de Melo… - FEMS Microbiology …, 2023 - academic.oup.com
Over the past few decades, the interest in lactic acid bacteria (LAB) has been steadily
growing. This is mainly due to their industrial use, their health benefits as probiotic bacteria …