Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …

Thin-layer chromatography (TLC) is widely used for food analysis and quality control. As an
open chromatographic system, TLC is compatible with microbial-, biochemical-, and …

The development of tyrosinase inhibitors to prevent the enzymatic browning have become a
research hotspot in food industry. 4-Hydroxycinnamic acid (CA) and ferulic acid (FA) are …

Tyrosinase is a copper-containing enzyme which is widely distributed in nature (eg, bacteria,
mammals, fungi) and involved in two consecutive steps of melanin biosynthesis. In humans …

Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its
inhibitors could be useful in preventing melanin-related diseases. To find potential …

Sclerotinia stem rot, which is caused by the fungal pathogen Sclerotinia sclerotiorum, is a
soybean disease that results in enormous economic losses worldwide. The control of S …

Develo** new anti-tyrosinase drugs seems crucial for the medical and industrial fields
since irregular melanin synthesis is linked to the resurgence of several skin conditions …

Cancer represents the main cause of morbidity and mortality worldwide, constituting a
serious health problem. In this context, melanoma represents the most aggressive and fatal …

Two novel kojic acid derivatives, kojicones A and B (1 and 2), along with the precursors kojic
acid (3) and (2R, 4R)-4-hydroxy-5-methoxy-2, 4-dimethyl-2-[(2R)-2-methylbutyryloxy]-5 …

Piperazine is a privileged moiety that is a structural part of many clinical drugs. Piperazine-
based scaffolds have attracted the attention of pharmaceutical and medicinal scientists to …