Role of cardiolipin in mitochondrial signaling pathways
J Dudek - Frontiers in cell and developmental biology, 2017 - frontiersin.org
The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes
and plays a role in many mitochondrial processes, including respiration and energy …
and plays a role in many mitochondrial processes, including respiration and energy …
[HTML][HTML] The protein import machinery of mitochondria—a regulatory hub in metabolism, stress, and disease
Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They
import more than 1,000 different proteins from the cytosol. It had been assumed that the …
import more than 1,000 different proteins from the cytosol. It had been assumed that the …
[HTML][HTML] Mitochondrial protein import: common principles and physiological networks
Most mitochondrial proteins are encoded in the nucleus. They are synthesized as precursor
forms in the cytosol and must be imported into mitochondria with the help of different protein …
forms in the cytosol and must be imported into mitochondria with the help of different protein …
Signaling and regulation of the mitochondrial unfolded protein response
The mitochondrial proteome encompasses more than a thousand proteins, which are
encoded by the mitochondrial and nuclear genomes. Mitochondrial biogenesis and network …
encoded by the mitochondrial and nuclear genomes. Mitochondrial biogenesis and network …
Unlocking the presequence import pathway
C Schulz, A Schendzielorz, P Rehling - Trends in cell biology, 2015 - cell.com
Translocation of presequence-containing precursor proteins into the inner mitochondrial
membrane and matrix is an essential process that is facilitated by the translocase of the …
membrane and matrix is an essential process that is facilitated by the translocase of the …
Cell cycle–dependent regulation of mitochondrial preprotein translocase
Mitochondria play central roles in cellular energy conversion, metabolism, and apoptosis.
Mitochondria import more than 1000 different proteins from the cytosol. It is unknown if the …
Mitochondria import more than 1000 different proteins from the cytosol. It is unknown if the …
Glucose-induced regulation of protein import receptor Tom22 by cytosolic and mitochondria-bound kinases
Most mitochondrial proteins are imported by the translocase of the outer mitochondrial
membrane (TOM). Tom22 functions as central receptor and transfers preproteins to the …
membrane (TOM). Tom22 functions as central receptor and transfers preproteins to the …
Cellular senescence and protein degradation: breaking down cancer
X Deschênes-Simard, F Lessard, MF Gaumont-Leclerc… - Cell Cycle, 2014 - Taylor & Francis
Autophagy and the ubiquitin–proteasome pathway (UPP) are the major protein degradation
systems in eukaryotic cells. Whereas the former mediate a bulk nonspecific degradation, the …
systems in eukaryotic cells. Whereas the former mediate a bulk nonspecific degradation, the …
Insights into the regulation of mitochondrial functions by protein kinase A-mediated phosphorylation
S Akabane, T Oka - The Journal of Biochemistry, 2024 - academic.oup.com
Cyclic AMP (cAMP)—protein kinase A (PKA) signaling is a highly conserved pathway in
eukaryotes and plays a central role in cell signaling cascades in response to environmental …
eukaryotes and plays a central role in cell signaling cascades in response to environmental …
Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import
The preprotein translocase of the outer mitochondrial membrane (TOM) functions as the
main entry gate for the import of nuclear-encoded proteins into mitochondria. The major …
main entry gate for the import of nuclear-encoded proteins into mitochondria. The major …