The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

For years, it has been reported that Alzheimer's disease (AD) is the most common cause of
dementia. Various external and internal factors may contribute to the early onset of AD. This …

Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment
currently exists. Previous genome-wide association studies with up to 1.3 million subjects …

Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are two
debilitating neurodevelopmental disorders. The former is associated with social impairments …

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong
genetic component in which rare variants contribute significantly to risk. We performed …

Recent genome-wide association studies on major depressive disorder have implicated
neuronal growth regulator 1 (Negr1), a GPI-anchored cell adhesion molecule in the …

In the brain, cell adhesion molecules (CAMs) are critical for neurite outgrowth, axonal
fasciculation, neuronal survival and migration, and synapse formation and maintenance …

Background and Objectives Anti-IgLON5 disease is an autoimmune neurodegenerative
disorder characterized by various phenotypes, notably sleep and movement disorders and …

Severe mental illnesses (SMI) collectively affect approximately 20% of the global population,
as estimated by the World Health Organization (WHO). Despite having diverse etiologies …

Anorexia nervosa (AN) is a complex metabolic and psychological disorder that is influenced
by both heritable genetic components and environmental factors. Exposure to various …