1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

The construction of carbon− carbon bonds, along with the creation of stereogenic carbon
centers, continues to be an appealing and demanding area of research, and processes in …

Multicomponent reactions have become increasingly popular as tools for the rapid
generation of small‐molecule libraries. However, to ensure sufficient molecular diversity and …

The chemistry of amines, amides, and other nitrogencontaining compounds plays a central
role in the organic synthesis. In fact, the first synthesized organic compound was urea. 1 The …

The use of secondary amines as asymmetric catalysts in transformations of carbonyl
compounds has seen tremendous development in recent years. Going from sporadic reports …

While organocatalyzed domino reactions or “organocascade catalysis” developed into an
important tool in synthetic chemistry during the past decade, the utility of N‐heterocyclic …

Multicomponent reactions (MCRs) receive increasing attention because they address both
diversity and complexity in organic synthesis. Thus, in principle diverse sets of relatively …

Catalysis with chiral secondary amines (asymmetric aminocatalysis) has become a well‐
established and powerful synthetic tool for the chemo‐and enantioselective functionalization …

Multicomponent reactions are one of the most interesting concepts in modern synthetic
chemistry and, as shown in this critical review, they provide an attractive entry into pyrrole …

A domino reaction has been defined by Tietze as a reaction involving two or more bond-
forming transformations that take place under the same reaction conditions, without adding …