Towards next-generation treatment options to combat Plasmodium falciparum malaria

J Okombo, DA Fidock - Nature Reviews Microbiology, 2024 - nature.com
Malaria, which is caused by infection of red blood cells with Plasmodium parasites, can be
fatal in non-immune individuals if left untreated. The recent approval of the pre-erythrocytic …

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo

SC **e, CW Tai, CJ Morton, L Ma, SC Huang… - PLoS …, 2024 - journals.plos.org
The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase (Pf TyrRS) is an attractive
drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside …

Host adaptation of Plasmodium falciparum translational control

Q Li - 2025 - openarchive.ki.se
Malaria, caused by the intracellular protozoan parasite Plasmodium falciparum, continues to
be a significant global health challenge. One of the major difficulties in combating the …