Gene therapy by expression constructs or down-regulation of certain genes has shown great
potential for the treatment of various diseases. The wide clinical application of nucleic acid …

Polymeric vehicles are versatile tools for therapeutic gene delivery. Many polymers—when
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …

Nanoparticle (NP)-based mRNA cancer vaccines hold great promise to realize personalized
cancer treatments. To advance this technology requires delivery formulations for efficient …

Therapeutic cancer vaccines require adjuvants leading to robust type I interferon and
proinflammatory cytokine responses in the tumor microenvironment to induce an anti-tumor …

Cancer is a major health issue concerning to all of us. Current treatment options are still
limited due to not-selective action. Encapsulation is contemplated as an innovative …

Abstract Poly (β‐amino ester)(abbreviated as PBAE or PAE) refers to a polymer synthesized
from an acrylate and an amine by Michael addition and has properties inherent to tertiary …

Introduction Gene delivery technologies are being developed for an increasing number of
biomedical applications, with delivery vehicles including viruses and non-viral materials …

Hepatocellular carcinoma (HCC) develops predominantly in the inflammatory environment
of a cirrhotic liver caused by hepatitis, toxin exposure, or chronic liver disease. A targeted …

Liver cancer is one of the most common cancers worldwide and is also one of the most
difficult cancers to treat, resulting in almost one million deaths per year, and the danger of …

Primary liver cancer has become the second most fatal cancer in the world, and its five-year
survival rate is only 10%. Most patients are in the middle and advanced stages at the time of …