ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

In this concise review, we summarize the concepts behind mRNA vaccination. We discuss
the innate and adaptive immune response generated by mRNA vaccines in different animal …

mRNA vaccines are rapidly emerging as a powerful platform for infectious diseases because
they are well tolerated, immunogenic, and scalable and are built on precise but adaptable …

Invariant natural killer T (iNKT) cells exist in a'poised effector'state, which enables them to
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …

High-density lipoproteins (HDL) are endogenous nanoparticles involved in the transport and
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …

The ɛ4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's
disease (AD). Although there have been numerous studies attempting to elucidate the …

Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

Alzheimer disease is a progressive dementia with unknown etiology that affects a growing
number of the aging population. Increased expression of inflammatory mediators in …

Three subsets of invariant natural killer T (iNKT) cells have been identified, NKT1, NKT2,
and NKT17, which produce distinct cytokines when stimulated, but little is known about their …

Tuberculosis (TB), an illness that mainly affects the respiratory system, is one of the world's
most pernicious diseases. TB currently infects one-third of the world's population and kills …