The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

The diversity in the biological response of 4-thiazolidinones has attracted the attention of
many researchers to explore this framework for its potential. It is, therefore, of prime …

R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

In contrast to studies on class I histone deacetylase (HDAC) inhibitors, the elucidation of the
molecular mechanisms and therapeutic potential of class IIa HDACs (HDAC4, HDAC5 …

This short review highlights some recent advances in matrix metalloproteinase inhibitor
(MMPi) design and development. Three distinct approaches to improved MMP inhibition are …

Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various
components of the extracellular matrix (ECM). MMPs could also regulate the activity of …

Periodontal diseases are initiated by Gram‐negative tooth‐associated microbial biofilms that
elicit a host response, with resultant osseous and soft tissue destruction. In response to …

Although matrix metalloproteinases (MMPs) are implicated in the regulation of numerous
physiological processes, evidence of their pathological roles have also been obtained in the …

Varicose veins (VVs) are a common venous disease of the lower extremity characterized by
incompetent valves, venous reflux, and dilated and tortuous veins. If untreated, VVs could …