[HTML][HTML] Influence of cholesterol on cancer progression and therapy

SS Mayengbam, A Singh, AD Pillai, MK Bhat - Translational oncology, 2021 - Elsevier
Cholesterol is a fundamental molecule necessary for the maintenance of cell structure and is
vital to various normal biological functions. It is a key factor in lifestyle-related diseases …

Advances in targeted therapy for acute myeloid leukemia

J Yu, PYZ Jiang, H Sun, X Zhang, Z Jiang, Y Li… - Biomarker …, 2020 - Springer
Acute myeloid leukemia (AML) is a clonal malignancy characterized by genetic
heterogeneity due to recurrent gene mutations. Treatment with cytotoxic chemotherapy has …

The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1/miR-26b/HMGA2 axis

C Zhao, X Ling, Y **a, B Yan, Q Guan - Cancer Cell International, 2021 - Springer
Background Previous studies have revealed the key functions of N6-methyladenosine (m6A)
modification in breast cancer (BC). MALAT1 as a highly m6A modified lncRNA associated …

A multidrug delivery microrobot for the synergistic treatment of cancer

Y Li, D Dong, Y Qu, J Li, S Chen, H Zhao, Q Zhang… - Small, 2023 - Wiley Online Library
Multidrug combination therapy provides an effective strategy for malignant tumor treatment.
This paper presents the development of a biodegradable microrobot for on‐demand …

Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy

Y Wu, X Pu, X Wang, M Xu - Lipids in Health and Disease, 2024 - Springer
Lipid metabolism in cancer cells has garnered increasing attention in recent decades.
Cancer cells thrive in hypoxic conditions, nutrient deficiency, and oxidative stress and …

Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein

HA El-Mahdy, AA El-Husseiny, YI Kandil, AMG El-Din - Life sciences, 2020 - Elsevier
Aim Pancreatic cancer (PC) is one of the most aggressive tumors with dismal survival and a
high death rate due to chemotherapeutic failure. P-glycoprotein (P-gp) plays a pivotal role in …

Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma

D Li, Y Yao, Y Rao, X Huang, L Wei, Z You… - Journal of Experimental …, 2022 - Springer
Background Hepatocellular carcinoma (HCC) is one of the most malignant tumors and the
fourth leading cause of cancer-related death worldwide. Sorafenib is currently …

miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis

B Lei, D Wang, M Zhang, Y Deng, H Jiang… - Journal of Experimental & …, 2020 - Springer
Background Increasing evidence indicates that epithelial-mesenchymal transition (EMT) can
be regulated by microRNAs (miRNAs). miR-615-3p was shown to be involved in tumor …

Synergistic effects of temozolomide and doxorubicin in the treatment of glioblastoma multiforme: enhancing efficacy through combination therapy

L Dhungel, ME Rowsey, C Harris, D Raucher - Molecules, 2024 - mdpi.com
Glioblastoma multiforme (GBM), a grade IV (WHO classification) malignant brain tumor,
poses significant challenges in treatment. The current standard treatment involves surgical …

Mechanistic understanding of Phenyllactic acid mediated inhibition of quorum sensing and biofilm development in Pseudomonas aeruginosa

M Chatterjee, S D'morris, V Paul, S Warrier… - Applied Microbiology …, 2017 - Springer
Pseudomonas aeruginosa depends on its quorum sensing (QS) system for its virulence
factors' production and biofilm formation. Biofilms of P. aeruginosa on the surface of …