A computational strategy to select optimized protein targets for drug development toward the control of cancer diseases

N Carels, T Tilli, JA Tuszynski - PLoS one, 2015 - journals.plos.org
In this report, we describe a strategy for the optimized selection of protein targets suitable for
drug development against neoplastic diseases taking the particular case of breast cancer as …

A metagenomic analysis of bacterial microbiota in the digestive tract of triatomines

N Carels, M Gumiel, FF da Mota… - … and Biology Insights, 2017 - journals.sagepub.com
The digestive tract of triatomines (DTT) is an ecological niche favored by microbiota whose
enzymatic profile is adapted to the specific substrate availability in this medium. This report …

[PDF][PDF] Optimization of combination chemotherapy based on the calculation of network entropy for protein-protein interactions in breast cancer cell lines

N Carels, TM Tilli, JA Tuszynski - EPJ Nonlinear Biomedical Physics, 2015 - Springer
Background In this report, we show how entropy computation can be applied to the
characterization of a protein-protein interaction networks to assist the selection of …

The purine bias of coding sequences is determined by physicochemical constraints on proteins

MP De Leon, AB De Miranda… - … and Biology insights, 2014 - journals.sagepub.com
For this report, we analyzed protein secondary structures in relation to the statistics of three
nucleotide codon positions. The purpose of this investigation was to find which properties of …

An interpretation of the ancestral codon from Miller's amino acids and nucleotide correlations in modern coding sequences

N Carels, MP de Leon - Bioinformatics and Biology insights, 2015 - journals.sagepub.com
Purine bias, which is usually referred to as an “ancestral codon”, is known to result in short-
range correlations between nucleotides in coding sequences, and it is common in all …

A history of genomic structures: The big picture

N Carels - Plant Biology and Biotechnology: Volume II: Plant …, 2015 - Springer
We present a comprehensive compilation of genomic structure evolution that should help
the reader who is not familiar with genomics to understand the mechanisms that are sha** …

Bioinformatics of infectious and chronic diseases at the Center for Technological Development in Health of Fiocruz

N Carels, GF da Silva, CR Lima… - … of Information and …, 2024 - journals-sol.sbc.org.br
One of the bioinformatics purposes is data mining and integration to solve fundamental
scientific challenges. We have been investigating biological systems including viruses …

System biology to access target relevance in the research and development of molecular inhibitors

L Catharina, MA de Menezes, N Carels - Theoretical and Applied Aspects …, 2018 - Springer
This review focuses on how system biology may assist techniques that are used in
pharmacological research, such as high-throughput screening, high-throughput analytical …

Functional genomics

LHF Gomes, M Alves-Ferreira, N Carels - Plant Biology and Biotechnology …, 2015 - Springer
Physiological responses, developmental programs, and cellular functions depend on
complex networks of interactions at different scales and levels. Systems biology unites …

Biotechnological approaches to growing green energy from Jatropha curcas: challenges due to the undomesticated status of the species.

F Maghuly, B Haas, M Laimer - CABI Reviews, 2016 - cabidigitallibrary.org
Jatropha curcas is one of the major tropical biofuel crops in the Euphorbiaceae family. The
species is an attractive candidate for biofuel production at industrial scale, for medicinal …