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A computational strategy to select optimized protein targets for drug development toward the control of cancer diseases
In this report, we describe a strategy for the optimized selection of protein targets suitable for
drug development against neoplastic diseases taking the particular case of breast cancer as …
drug development against neoplastic diseases taking the particular case of breast cancer as …
A metagenomic analysis of bacterial microbiota in the digestive tract of triatomines
N Carels, M Gumiel, FF da Mota… - … and Biology Insights, 2017 - journals.sagepub.com
The digestive tract of triatomines (DTT) is an ecological niche favored by microbiota whose
enzymatic profile is adapted to the specific substrate availability in this medium. This report …
enzymatic profile is adapted to the specific substrate availability in this medium. This report …
[PDF][PDF] Optimization of combination chemotherapy based on the calculation of network entropy for protein-protein interactions in breast cancer cell lines
Background In this report, we show how entropy computation can be applied to the
characterization of a protein-protein interaction networks to assist the selection of …
characterization of a protein-protein interaction networks to assist the selection of …
The purine bias of coding sequences is determined by physicochemical constraints on proteins
MP De Leon, AB De Miranda… - … and Biology insights, 2014 - journals.sagepub.com
For this report, we analyzed protein secondary structures in relation to the statistics of three
nucleotide codon positions. The purpose of this investigation was to find which properties of …
nucleotide codon positions. The purpose of this investigation was to find which properties of …
An interpretation of the ancestral codon from Miller's amino acids and nucleotide correlations in modern coding sequences
Purine bias, which is usually referred to as an “ancestral codon”, is known to result in short-
range correlations between nucleotides in coding sequences, and it is common in all …
range correlations between nucleotides in coding sequences, and it is common in all …
A history of genomic structures: The big picture
N Carels - Plant Biology and Biotechnology: Volume II: Plant …, 2015 - Springer
We present a comprehensive compilation of genomic structure evolution that should help
the reader who is not familiar with genomics to understand the mechanisms that are sha** …
the reader who is not familiar with genomics to understand the mechanisms that are sha** …
Bioinformatics of infectious and chronic diseases at the Center for Technological Development in Health of Fiocruz
N Carels, GF da Silva, CR Lima… - … of Information and …, 2024 - journals-sol.sbc.org.br
One of the bioinformatics purposes is data mining and integration to solve fundamental
scientific challenges. We have been investigating biological systems including viruses …
scientific challenges. We have been investigating biological systems including viruses …
System biology to access target relevance in the research and development of molecular inhibitors
This review focuses on how system biology may assist techniques that are used in
pharmacological research, such as high-throughput screening, high-throughput analytical …
pharmacological research, such as high-throughput screening, high-throughput analytical …
Functional genomics
LHF Gomes, M Alves-Ferreira, N Carels - Plant Biology and Biotechnology …, 2015 - Springer
Physiological responses, developmental programs, and cellular functions depend on
complex networks of interactions at different scales and levels. Systems biology unites …
complex networks of interactions at different scales and levels. Systems biology unites …
Biotechnological approaches to growing green energy from Jatropha curcas: challenges due to the undomesticated status of the species.
Jatropha curcas is one of the major tropical biofuel crops in the Euphorbiaceae family. The
species is an attractive candidate for biofuel production at industrial scale, for medicinal …
species is an attractive candidate for biofuel production at industrial scale, for medicinal …