Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans

SK Torzone, AY Park, PC Breen, NR Cohen… - PLoS …, 2023 - journals.plos.org
Animals integrate developmental and nutritional signals before committing crucial resources
to growth and reproduction; however, the pathways that perceive and respond to these …

Targeting cAMP signaling compartments in iPSC-derived models of cardiovascular disease

T Liu, E Klussmann - Current Opinion in Pharmacology, 2023 - Elsevier
Abstract Adenosine 3′, 5′-cyclic monophosphate (cAMP) acts as a second messenger
that is involved in the regulation of a plethora of processes. The activation of cAMP signaling …

Detection of PRKAR1A gene mutations in sporadic cardiac myxomas: a study of 24 cases

E Bekers, DAG van Bladel, MR Berendsen… - Virchows Archiv, 2025 - Springer
The benign neoplasm cardiac myxoma represents one of the hallmarks of Carney complex
(CNC), a familial multiple neoplasia syndrome. About 80% of the index cases have germline …

PKA Activity-Driven Modulation of Bidirectional Long-Distance transport of Lysosomal vesicles During Synapse Maintenance

KK Badal, Y Zhao, BL Raveendra, S Lozano-Villada… - …, 2024 - pmc.ncbi.nlm.nih.gov
The bidirectional long-distance transport of organelles is crucial for cell body-synapse
communication. However, the mechanisms by which this transport is modulated for synapse …

STK25 is an IRF5 kinase that promotes TLR7/8-mediated inflammation

MR Rice, B Matta, L Wang, S Indukuri, BJ Barnes - bioRxiv, 2023 - biorxiv.org
Toll-like receptors (TLRs) represent a subset of pattern-recognition receptors (PRRs)
employed by the innate immune system to detect pathogen-associated molecular patterns …

Effects of Phosphorylation of Tropomyosin with Cardiomyopathic Mutations on Calcium Regulation of Myocardial Contraction

GV Kopylova, AM Matyushenko, AM Kochurova… - Journal of Evolutionary …, 2022 - Springer
Mutations in the TPM1. 1 gene lead to the development of cardiomyopathies. It has been
shown that in cardiomyopathies there is a change in the degree of tropomyosin …

[PDF][PDF] The detection of stress-related diseases: establishment of two unique methods to discover circulatory phospho-and glycoproteins

LJ Smith - 2023 - scholar.sun.ac.za
In 1936, a young medical student named Hans Selye wrote a letter to the editor of Nature
where he coined “the general adaptation syndrome”(581). Many years later, this concept is …

Follicle stimulating hormone signaling opposes the DRL-1/FLR-4 MAP Kinases to balance p38-mediated growth and lipid homeostasis in C. elegans

SK Torzone, AY Park, PC Breen, NR Cohen… - bioRxiv, 2023 - biorxiv.org
Animals integrate developmental and nutritional signals before committing crucial resources
to growth and reproduction; however, the pathways that perceive and respond to these …