Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …

The shapes of eukaryotic cells and ultimately the organisms that they form are defined by
cycles of mechanosensing, mechanotransduction and mechanoresponse. Local sensing of …

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix
ligands, cell-surface ligands, and soluble ligands. They are transmembrane αβ heterodimers …

It has been brought to our attention that there is an error in the poster published in
association with this article. Non-phosphorylated ICAP1 is shown to bind to the cytoplasmic …

Hypertensive heart disease (HHD) occurs in patients that clinically have both diastolic and
systolic heart failure and will soon become the most common cause of heart failure. Two key …

Focal adhesions (FAs) regulate cell migration. Vinculin, with its many potential binding
partners, can interconnect signals in FAs. Despite the well-characterized structure of …

The complex interactions of cells with extracellular matrix (ECM) play crucial roles in
mediating and regulating many processes, including cell adhesion, migration, and signaling …