The current 2019–2021 marine pharmacology literature review provides a continuation of
previous reviews covering the period 1998 to 2018. Preclinical marine pharmacology …

The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

Sulfur-containing natural products (S-containing NPs) exhibit diverse chemical structures
and biosynthetic machineries. Unraveling the intricate chemistry of S-incorporation requires …

Ovothiol A and ergothioneine are thiol-histidine derivatives with sulfur substitutions at the δ-
carbon or ε-carbon of the l-histidine imidazole ring, respectively. Both ovothiol A and …

Cancer and oxidative stress are interrelated, with reactive oxygen species (ROS) playing
crucial roles in physiological processes and oncogenesis. Excessive ROS levels can induce …

Marine cyanobacterial bioactives, due to their diverse chemistry and promising
pharmacological properties, hold significant potential as therapeutic agents. Here, we …

Peptides are increasingly important drug candidates, offering numerous advantages over
conventional small molecules. However, they face significant challenges related to stability …

Bridged peptide macrobicycles (BPMs) from natural resources belong to types of
compounds that are not investigated fully in terms of their formation, pharmacological …

Technological advancement to enhance tumor cells (TC) has allowed discovery of various
cellular bio-markers: cancer stem cells (CSC), circulating tumor cells (CTC), and endothelial …

Cyclopolypeptides are among the most predominant biomolecules in nature, especially
those derived from plant seeds. This category of compounds has gained extraordinary …