Pyrazolo [1, 5-a] pyrimidines are the dominant motif of many drugs; for instance, zaleplon
and indiplon are sedative agents and ocinaplon was identified as an anxiolytic agent. The …

Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …

Searching for new compounds with anti-inflammatory properties is a significant target since
inflammation is a major cause of pain. A series of pyrazole, imidazopyrazolone, and …

Nowadays, searching for new anti-infective agents with diverse mechanisms of action has
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …

An efficient and environmentally friendly method was established for designing novel 3-
amino-1, 4-dihydroquinoxaline-2-carbonitrile (1) via the reaction of bromomalononitrile and …

Anti-inflammatory medications are one of the most commonly preferred over-the-counter
medications because inflammation and pain are closely related and caused by various …

Chronic inflammation contributes to a number of diseases. Therefore, control of the
inflammatory response is an important therapeutic goal. To identify novel anti-inflammatory …

Recently, there has been an increased interest in develo** new antibacterial agents that
target the MurB inhibition, which is necessary for bacterial survival. We developed a two …

NSAIDs represent a mainstay in pain and inflammation suppression, and their actions are
mainly based on inhibiting COX-1 and COX-2 enzymes. Due to the adverse effects of these …

In this article, novel thiazol-indolin-2-one derivatives 4a–f have been synthesized via
treatment of thiosemicarbazide (1) with some isatin derivative 2a–f and N-(4-(2-bromoacetyl) …