One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

Immune cells are characterized by diversity, specificity, plasticity, and adaptability—
properties that enable them to contribute to homeostasis and respond specifically and …

Pharmacologically-induced activation of replication competent proviruses from latency in the
presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV …

Spontaneous transcription and translation of HIV can persist during suppressive
antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this …

Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in
antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and …

Although understanding the diversity of HIV-1 reservoirs is key to achieving a cure, their
study at the single-cell level in primary samples remains challenging. We combine flow …

Despite effective treatment, HIV can persist in latent reservoirs, which represent a major
obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to …

Latently-infected CD4+ T cells are widely considered to be the major barrier to a cure for
HIV. Much of our understanding of HIV latency comes from latency models and blood cells …

A detailed understanding of the mechanisms that establish or maintain the latent reservoir of
HIV will guide approaches to eliminate persistent infection. We used a cell line and primary …

Recent years have seen a substantial increase in the number of tools available to monitor
and study HIV reservoirs. Here, we discuss recent technological advances that enable an …