Exosomes as a new frontier of cancer liquid biopsy

D Yu, Y Li, M Wang, J Gu, W Xu, H Cai, X Fang… - Molecular cancer, 2022 - Springer
Liquid biopsy, characterized by minimally invasive detection through biofluids such as
blood, saliva, and urine, has emerged as a revolutionary strategy for cancer diagnosis and …

Comprehensive isolation of extracellular vesicles and nanoparticles

Q Zhang, DK Jeppesen, JN Higginbotham… - Nature protocols, 2023 - nature.com
There is an increasing appreciation for the heterogeneous nature of extracellular vesicles
(EVs). In addition, two nonvesicular extracellular nanoparticles (NVEPs), exomeres and …

Designing nanotheranostics with machine learning

L Rao, Y Yuan, X Shen, G Yu, X Chen - Nature Nanotechnology, 2024 - nature.com
The inherent limits of traditional diagnoses and therapies have driven the development and
application of emerging nanotechnologies for more effective and safer management of …

Molecular characterization of exosomes for subtype-based diagnosis of breast cancer

Y Cao, X Yu, T Zeng, Z Fu, Y Zhao, B Nie… - Journal of the …, 2022 - ACS Publications
Breast cancer is very heterogeneous and the most frequently diagnosed cancer worldwide,
and precise therapy targeting specific subtypes may improve the survival rates of breast …

Recent developments in isolating methods for exosomes

J Gao, A Li, J Hu, L Feng, L Liu, Z Shen - Frontiers in bioengineering …, 2023 - frontiersin.org
Exosomes are the smallest extracellular vesicles that can be released by practically all cell
types, and range in size from 30 nm to 150 nm. As the major marker of liquid biopsies …

Future of digital assays to resolve clinical heterogeneity of single extracellular vesicles

RTT Morales, J Ko - ACS nano, 2022 - ACS Publications
Extracellular vesicles (EVs) are complex lipid membrane vehicles with variable expressions
of molecular cargo, composed of diverse subpopulations that participate in the intercellular …

One‐Step Thermophoretic AND Gate Operation on Extracellular Vesicles Improves Diagnosis of Prostate Cancer

J Deng, S Zhao, J Li, Y Cheng, C Liu… - Angewandte Chemie …, 2022 - Wiley Online Library
Circulating extracellular vesicles (EVs) have emerged as a valuable source of cancer
biomarkers. However, the high degree of EV heterogeneity and the complexity of clinical …

[HTML][HTML] Microfluidic-based exosome isolation and highly sensitive aptamer exosome membrane protein detection for lung cancer diagnosis

L Zhao, H Wang, J Fu, X Wu, X Liang, X Liu… - Biosensors and …, 2022 - Elsevier
Non-invasive methods of detecting cancer by circulating exosomes are challenged by
inefficient purification and identification. This study hereby proposed an automated …

Exosome metabolic patterns on aptamer-coupled polymorphic carbon for precise detection of early gastric cancer

H Chen, C Huang, Y Wu, N Sun, C Deng - ACS nano, 2022 - ACS Publications
Gastric cancer (GC) presents high mortality worldwide because of delayed diagnosis.
Currently, exosome-based liquid biopsy has been applied in diagnosis and monitoring of …

Theranostic signature of tumor-derived exosomes in cancer

S Kumar, R Dhar, LBSS Kumar, GG Shivji, R Jayaraj… - Medical Oncology, 2023 - Springer
Cancer is the most challenging global health crisis. In the recent times, studies on
extracellular vesicles (EVs) are adding a new chapter to cancer research and reports on EVs …