Fused diaza-heterocycles constitute the core structure of numerous bioactive natural
products and effective therapeutic drugs. Among them, phthalazines have been recognized …

Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-
nucleoside selective telomerase inhibitor; however, it experiences ineligible …

Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes known to play a
critical role in the indirect regulation of several intracellular metabolism pathways through …

As a progressive neuropathic condition, glaucoma can cause lifelong blindness if left
untreated. Novel phenylpyridazine-tethered sulfonamides were designed as selective …

In this work, additional effort was applied to design new BIBR1532-based analogues with
potential inhibitory activity against telomerase and acting as multitarget antitumor candidates …

A variety of functionalized indazoles are brominated in moderate to excellent yields using N-
bromosuccinimide (NBS) under visible-light activated conditions. A screening of organic dye …

Inhibition of PDE5 results in elevation of cGMP leading to vascular relaxation and reduction
in the systemic blood pressure. Therefore, PDE5 inhibitors are used as antihypertensive and …

The study uses in-vitro antioxidant, ex-vivo enzyme kinetics and in-silico approach using
standard protocols to understand their inhibitory mechanism better. The study revealed that …

Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory nervous system. It is accompanied by neuronal and non-neuronal …

Pyridazinone analogs possess diverse types of pharmacological activities, such as
anticancer, antimicrobial, anticonvulsant, analgesic, anti-inflammatory, antioxidant …