The study of homologous recombination has its historical roots in meiosis. In this context,
recombination occurs as a programmed event that culminates in the formation of crossovers …

Disease-causing repeat instability is an important and unique form of mutation that is linked
to more than 40 neurological, neurodegenerative and neuromuscular disorders. DNA repeat …

Reproductive longevity is essential for fertility and influences healthy ageing in women,, but
insights into its underlying biological mechanisms and treatments to preserve it are limited …

Meiosis, the mechanism of creating haploid gametes, is a complex cellular process
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …

Aneuploidy is the most common chromosome abnormality in humans, and is the leading
genetic cause of miscarriage and congenital birth defects. Since the identification of the first …

The leading cause of infertility in men and women is quantitative and qualitative defects in
human germ-cell (oocyte and sperm) development. Yet, it has not been possible to examine …

ABSTRACT BACKGROUND The unbalanced transmission of chromosomes in human
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …

Crossover recombination reshuffles genes and prevents errors in segregation that lead to
extra or missing chromosomes (aneuploidy) in human eggs, a major cause of pregnancy …

Meiosis is one of the defining events in gametogenesis. Male and female germ cells both
undergo one round of meiotic cell division during their development in order to reduce the …

Critical events of oogenesis occur during three distinct developmental stages: meiotic
initiation in the fetal ovary, follicle formation in the perinatal period, and oocyte growth and …