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Stimuli-responsive polymer-based nanosystems for cancer theranostics
D Wei, Y Sun, H Zhu, Q Fu - ACS nano, 2023 - ACS Publications
Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen
species (ROS), glutathione (GSH), and pH, biological stimuli, such as enzymes, and external …
species (ROS), glutathione (GSH), and pH, biological stimuli, such as enzymes, and external …
New developments in RiPP discovery, enzymology and engineering
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …
A general copper-catalysed enantioconvergent C(sp3)–S cross-coupling via biomimetic radical homolytic substitution
Y Tian, XT Li, JR Liu, J Cheng, A Gao, NY Yang, Z Li… - Nature Chemistry, 2024 - nature.com
Although α-chiral C (sp 3)–S bonds are of enormous importance in organic synthesis and
related areas, the transition-metal-catalysed enantioselective C (sp 3)–S bond construction …
related areas, the transition-metal-catalysed enantioselective C (sp 3)–S bond construction …
[HTML][HTML] Bacteriocins, potent antimicrobial peptides and the fight against multi drug resistant species: resistance is futile?
Despite highly specialized international interventions and policies in place today, the rapid
emergence and dissemination of resistant bacterial species continue to occur globally …
emergence and dissemination of resistant bacterial species continue to occur globally …
Darobactin substrate engineering and computation show radical stability governs ether versus C–C bond formation
AM Woodard, F Peccati, CD Navo… - Journal of the …, 2024 - ACS Publications
The Gram-negative selective antibiotic darobactin A has attracted interest owing to its
intriguing fused bicyclic structure and unique targeting of the outer membrane protein BamA …
intriguing fused bicyclic structure and unique targeting of the outer membrane protein BamA …
Substrate-controlled catalysis in the ether cross-link-forming radical SAM enzymes
S Ma, W ** of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ …
GA Hudson, BJ Burkhart, AJ DiCaprio… - Journal of the …, 2019 - ACS Publications
Recently developed bioinformatic tools have bolstered the discovery of ribosomally
synthesized and post-translationally modified peptides (RiPPs). Using an improved version …
synthesized and post-translationally modified peptides (RiPPs). Using an improved version …
Characterization of a radical SAM oxygenase for the ether crosslinking in darobactin biosynthesis
Darobactin A is a ribosomally synthesized, post-translationally modified peptide (RiPP) with
potent and broad-spectrum anti-Gram-negative antibiotic activity. The structure of darobactin …
potent and broad-spectrum anti-Gram-negative antibiotic activity. The structure of darobactin …
Biocompatible strategies for peptide macrocyclisation
Peptides are increasingly important drug candidates, offering numerous advantages over
conventional small molecules. However, they face significant challenges related to stability …
conventional small molecules. However, they face significant challenges related to stability …
Post-translational formation of strained cyclophanes in bacteria
Cyclic peptide natural products have served as important drug molecules, with several
examples used clinically. Enzymatic or chemical macrocyclization is the key transformation …
examples used clinically. Enzymatic or chemical macrocyclization is the key transformation …