Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
Multivalent glycoconjugates as anti-pathogenic agents
Multivalency plays a major role in biological processes and particularly in the relationship
between pathogenic microorganisms and their host that involves protein–glycan recognition …
between pathogenic microorganisms and their host that involves protein–glycan recognition …
Dendrimers in biomedical applications—reflections on the field
S Svenson, DA Tomalia - Advanced drug delivery reviews, 2012 - Elsevier
The formation of particulate systems with well-defined sizes and shapes is of eminent
interest in certain medical applications such as drug delivery, gene transfection, and …
interest in certain medical applications such as drug delivery, gene transfection, and …
Dendrimers in drug research
U Boas, PMH Heegaard - Chemical Society Reviews, 2004 - pubs.rsc.org
Dendrimers are versatile, derivatisable, well-defined, compartmentalised chemical polymers
with sizes and physicochemical properties resembling those of biomolecules eg proteins …
with sizes and physicochemical properties resembling those of biomolecules eg proteins …
Carbohydrates as future anti-adhesion drugs for infectious diseases
N Sharon - Biochimica et Biophysica Acta (BBA)-General Subjects, 2006 - Elsevier
Adhesion of pathogenic organisms to host tissues is the prerequisite for the initiation of the
majority of infectious diseases. In many systems, it is mediated by lectins present on the …
majority of infectious diseases. In many systems, it is mediated by lectins present on the …
Receptor binding studies disclose a novel class of high‐affinity inhibitors of the Escherichia coli FimH adhesin
Mannose‐binding type 1 pili are important virulence factors for the establishment of
Escherichia coli urinary tract infections (UTIs). These infections are initiated by adhesion of …
Escherichia coli urinary tract infections (UTIs). These infections are initiated by adhesion of …
Prebiotic Galactooligosaccharides Reduce Adherence of Enteropathogenic Escherichia coli to Tissue Culture Cells
K Shoaf, GL Mulvey, GD Armstrong… - Infection and …, 2006 - Am Soc Microbiol
Prebiotic oligosaccharides are thought to provide beneficial effects in the gastrointestinal
tract of humans and animals by stimulating growth of selected members of the intestinal …
tract of humans and animals by stimulating growth of selected members of the intestinal …
Biological applications of dendrimers
MJ Cloninger - Current opinion in chemical biology, 2002 - Elsevier
In the past year, significant advances have been made in the synthesis and study of
glycodendrimers and peptide dendrimers. Application of these dendrimers to the study of …
glycodendrimers and peptide dendrimers. Application of these dendrimers to the study of …
A guide into glycosciences: how chemistry, biochemistry and biology cooperate to crack the sugar code
D Solis, NV Bovin, AP Davis, J Jiménez-Barbero… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Background The most demanding challenge in research on molecular aspects within the
flow of biological information is posed by the complex carbohydrates (glycan part of cellular …
flow of biological information is posed by the complex carbohydrates (glycan part of cellular …
Maximising multivalency effects in protein–carbohydrate interactions
RJ Pieters - Organic & biomolecular chemistry, 2009 - pubs.rsc.org
Multivalent carbohydrates are currently produced in many forms ranging from dendrimers,
polymers, micelles, vesicles, nanoparticles to functionalized nanotubes, in order to enhance …
polymers, micelles, vesicles, nanoparticles to functionalized nanotubes, in order to enhance …