A retrospect study on thiazole derivatives as the potential antidiabetic agents in drug discovery and developments
Background: Heterocycles containing thiazole, a moiety with sulfur and nitrogen is a core
structure which is found in a number of biologically active compounds. The thiazole ring is …
structure which is found in a number of biologically active compounds. The thiazole ring is …
A review on advances in organoborane-chemistry: versatile tool in asymmetric synthesis
Background: In the past decades, the hydroboration reaction was serendipitously
discovered which occurred by the facile addition of diborane to alkenes and alkynes …
discovered which occurred by the facile addition of diborane to alkenes and alkynes …
Synthesis, DFT investigation, molecular docking analysis, ADMET studies, and biological evaluation of a novel series of imidazolidinone derivatives as potential …
In this study, we constructed twenty novel imidazolidinone derivatives via the reaction of 2-
(methylthio)-3, 5-dihydro-4H-imidazol-4-one derivatives (1a-c) with some active methylene …
(methylthio)-3, 5-dihydro-4H-imidazol-4-one derivatives (1a-c) with some active methylene …
“On-water” synthesis of thioxoimidazolidinone-isatin/ninhydrin conjugates, followed by temperature-induced dehydration by a ZnMnO 3@ Ni (OH) 2 nano-catalyst
A novel and efficient “on water” mediated one-pot ZnMnO3@ Ni (OH) 2 catalyzed straight-
forward synthesis of 3-hydroxy-3-(3-methyl-5-oxo-2-thioxoimidazolidin-4-yl) oxindole via a …
forward synthesis of 3-hydroxy-3-(3-methyl-5-oxo-2-thioxoimidazolidin-4-yl) oxindole via a …
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as antiproliferative agents: A combined experimental and theoretical assessments
In our endeavors to develop potent anticancer agents, novel two series of 3, 5-disubstituted-
2-thiohydantoins 5a–c and the S-methyl counterparts 6a–c were designed and synthesized …
2-thiohydantoins 5a–c and the S-methyl counterparts 6a–c were designed and synthesized …
A catalyst free, one pot approach for the synthesis of quinoxaline derivatives via oxidative cyclisation of 1, 2-diamines and phenacyl bromides
A catalyst free, one pot approach for the synthesis of quinoxaline derivatives via oxidative
cyclisation of 1,2-diamines and phenacyl bromides - ScienceDirect Skip to main contentSkip to …
cyclisation of 1,2-diamines and phenacyl bromides - ScienceDirect Skip to main contentSkip to …
Regiospecific epoxide opening: a facile approach for the synthesis of 3-hydroxy-3-aminomethylindolin-2-one derivatives
A mild and eco-friendly method has been developed for aminolysis of 3-oxirane-indolin-2-
ones with aliphatic and aromatic amines to afford 3-hydroxy-3-aminomethylindolin-2-ones …
ones with aliphatic and aromatic amines to afford 3-hydroxy-3-aminomethylindolin-2-ones …
Reversal of Selectivity in Acetate Aldol Reactions of N-Acetyl-(S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one
Synergistic effects of the exo-and endocyclic chiral centers of an imidazolidinone-based
auxiliary were investigated in the perspective of acetate aldol reactions. The reversal in …
auxiliary were investigated in the perspective of acetate aldol reactions. The reversal in …
1, 2, 4-Oxadiazoles: A new class of anti-prostate cancer agents
Sulfide and sulfonyl derivatives of 1, 2, 4-oxadiazoles were synthesized and screened by
MTT assay on the prostate cancer cells, DU-145. Six compounds were identified as potential …
MTT assay on the prostate cancer cells, DU-145. Six compounds were identified as potential …
Design and development of oxobenzimidazoles as novel androgen receptor antagonists
R Elancheran, K Saravanan, B Choudhury… - Medicinal Chemistry …, 2016 - Springer
Antiandrogens are a novel class of anticancer agents that inhibit cancer cell proliferation
and induce apoptosis in various cell lines. To find the lead compound from the …
and induce apoptosis in various cell lines. To find the lead compound from the …