Maintenance of skeletal muscle quantity and quality is essential to ensure various vital
functions of the body. Muscle homeostasis is regulated by multiple cytoskeletal proteins and …

The actin containing tropomyosin and troponin decorated thin filaments form one of the
crucial components of the contractile apparatus in muscles. The thin filaments are organized …

Sustained muscle contraction occurs through interactions between actin and myosin
filaments within sarcomeres and requires a constant supply of adenosine triphosphate (ATP) …

To better understand the genetic basis of heart disease, we identified a variant in the
Flightless-I homolog (FLII) gene that generates a R1243H missense change and …

During early embryogenesis, as cells divide in the develo** embryo, the size of
intracellular organelles generally decreases to scale with the decrease in overall cell size …

During striated muscle development the first periodically repeated units appear in the
premyofibrils, consisting of immature sarcomeres that must undergo a substantial growth …

Disorganization of the basic contractile unit of muscle cells, ie, the sarcomeres, leads to
suboptimal force generation and is a hallmark of muscle atrophy. Here, we demonstrate that …

Skeletal muscles play a central role in human movement through forces transmitted by
contraction of the sarcomere. We recently showed that mammalian sarcomeres are …

REF52 fibroblasts have a well-developed contractile machinery, the most prominent
elements of which are actomyosin stress fibers with highly ordered organization of actin and …

Drosophila embryonic somatic muscles represent a simple and tractable model system to
study the gene regulatory networks that control diversification of cell types. Somatic …