Prompted by the ground-breaking discovery of the rodent odorant receptor (OR) gene family
within the olfactory epithelium nearly 30 years ago, followed by that of OR genes in cells of …

The field of chemical senses has made major progress in understanding the cellular
mechanisms of olfaction and taste in the past 2 decades. However, the molecular …

Understanding olfaction at the molecular level is challenging due to the lack of
crystallographic models of odorant receptors (ORs). To better understand the molecular …

This review reports on the knowledge about odourant–olfactory receptor interactions and
their projection within the field of structure–odour relationships (SOR). We provide a list of …

Highlights•The time is right for applying machine learning (ML) for GPCR drug
discovery.•For many GPCRs lacking 3D structure, ML ligand-based methods have replaced …

Odorant receptor (OR) genes and proteins represent more than 2% of our genome and 4%
of our proteome and constitute the largest subgroup of G protein-coupled receptors …

Odor perception in humans is initiated by activation of odorant receptors (ORs) in the nose.
However, the ORs linked to specific olfactory percepts are unknown, unlike in vision or taste …

Deciphering how an odorant activates an odorant receptor (OR) and how changes in
specific OR residues affect its responsiveness are central to understanding our sense of …

G protein-coupled receptors (GPCRs), especially the class A, are the most heavily
investigated drug targets in the pharmaceutical industry. Tremendous efforts have been …

In numerous insects, the olfactory receptor family forms a unique class of heteromeric cation
channels. Recent progress in resolving the odorant receptor structures offers unprecedented …