Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

P Asgharian, AP Tazekand, K Hosseini… - Cancer cell …, 2022 - Springer
Over the past few years, the cancer-related disease has had a high mortality rate and
incidence worldwide, despite clinical advances in cancer treatment. The drugs used for …

Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

J Sharifi-Rad, V Seidel, M Izabela… - Cell Communication and …, 2023 - Springer
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism.
The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative …

Bioactive natural products in COVID-19 therapy

Z Wang, N Wang, L Yang, X Song - Frontiers in Pharmacology, 2022 - frontiersin.org
The devastating COVID-19 pandemic has caused more than six million deaths worldwide
during the last 2 years. Effective therapeutic agents are greatly needed, yet promising magic …

[HTML][HTML] Assessment of quercetin antiemetic properties: in vivo and in silico investigations on receptor binding affinity and synergistic effects

R Chowdhury, MS Bhuia, AI Rakib, R Hasan… - Plants, 2023 - mdpi.com
Quercetin (QUA), a flavonoid compound, is ubiquitously found in plants and has
demonstrated a diverse range of biological activities. The primary objective of the current …

[HTML][HTML] Multi-target mechanisms of phytochemicals in Alzheimer's disease: Effects on oxidative stress, neuroinflammation and protein aggregation

J Sharifi-Rad, S Rapposelli, S Sestito… - Journal of Personalized …, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a tangle-shaped
accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The …

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

ES Ali, S Akter, S Ramproshad, B Mondal… - Cancer cell …, 2022 - Springer
MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase)
pathway is an important link in the transition from extracellular signals to intracellular …

Gigantol, a promising natural drug for inflammation: a literature review and computational based study

R Chowdhury, S Bhuia, AI Rakib… - Natural Product …, 2024 - Taylor & Francis
Gigantol, a bibenzyl compound extracted from various medicinal plants, has shown a
number of biological activities, making it an attractive candidate for potential medical …

Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update

P Asgharian, C Quispe, J Herrera-Bravo… - Frontiers in …, 2022 - frontiersin.org
Neuropsychiatric diseases are a group of disorders that cause significant morbidity and
disability. The symptoms of psychiatric disorders include anxiety, depression, eating …

[HTML][HTML] Therapeutic implications of quercetin and its derived-products in COVID-19 protection and prophylactic

WY Ho, Z Shen, Y Chen, TH Chen, XL Lu, YS Fu - Heliyon, 2024 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel human
coronavirus, which has triggered a global pandemic of the coronavirus infectious disease …