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Scanning probe microscopy
Scanning probe microscopy (SPM), a key invention in nanoscience, has by now been
extended to a wide spectrum of basic and applied fields. Its application to basic science led …
extended to a wide spectrum of basic and applied fields. Its application to basic science led …
Modeling and control of piezo-actuated nanopositioning stages: A survey
Piezo-actuated stages have become more and more promising in nanopositioning
applications due to the excellent advantages of the fast response time, large mechanical …
applications due to the excellent advantages of the fast response time, large mechanical …
Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism
Structural maintenance of chromosomes (SMC) complexes organize genome topology in all
kingdoms of life and have been proposed to perform this function by DNA loop extrusion …
kingdoms of life and have been proposed to perform this function by DNA loop extrusion …
Structure of the mitochondrial import gate reveals distinct preprotein paths
The translocase of the outer mitochondrial membrane (TOM) is the main entry gate for
proteins,,–. Here we use cryo-electron microscopy to report the structure of the yeast TOM …
proteins,,–. Here we use cryo-electron microscopy to report the structure of the yeast TOM …
Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography
The abuse of antibiotics has led to the emergence of multidrug-resistant microbial
pathogens, presenting a pressing challenge in global healthcare. Membrane-disrupting …
pathogens, presenting a pressing challenge in global healthcare. Membrane-disrupting …
[HTML][HTML] The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy
Mitophagy plays an important role in mitochondrial homeostasis by selective degradation of
mitochondria. During mitophagy, mitochondria should be fragmented to allow engulfment …
mitochondria. During mitophagy, mitochondria should be fragmented to allow engulfment …
Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy
The CRISPR-associated endonuclease Cas9 binds to a guide RNA and cleaves double-
stranded DNA with a sequence complementary to the RNA guide. The Cas9–RNA system …
stranded DNA with a sequence complementary to the RNA guide. The Cas9–RNA system …
High-speed atomic force microscopy reveals structural dynamics of amyloid β1–42 aggregates
Aggregation of amyloidogenic proteins into insoluble amyloid fibrils is implicated in various
neurodegenerative diseases. This process involves protein assembly into oligomeric …
neurodegenerative diseases. This process involves protein assembly into oligomeric …
[HTML][HTML] The intrinsically disordered protein Atg13 mediates supramolecular assembly of autophagy initiation complexes
Autophagosome formation in yeast entails starvation-induced assembly of the pre-
autophagosomal structure (PAS), in which multiple Atg1 complexes (composed of Atg1 …
autophagosomal structure (PAS), in which multiple Atg1 complexes (composed of Atg1 …
[HTML][HTML] Emerging critical roles of Fe–S clusters in DNA replication and repair
Fe–S clusters are partners in the origin of life that predate cells, acetyl-CoA metabolism,
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …