[HTML][HTML] Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms
S Chen, D Gan, S Lin, Y Zhong, M Chen, X Zou… - Theranostics, 2022 - ncbi.nlm.nih.gov
Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …
Metformin and systemic metabolism
L He - Trends in Pharmacological Sciences, 2020 - cell.com
Metformin can improve patients' hyperglycemia through significant suppression of hepatic
glucose production. However, up to 300 times higher concentrations of metformin …
glucose production. However, up to 300 times higher concentrations of metformin …
Organic cation transporters in health and disease
H Koepsell, LC Daws - Pharmacological reviews, 2020 - Elsevier
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin
Metformin use is associated with reduced cancer mortality, but how metformin impacts
cancer outcomes is controversial. Although metformin can act on cells autonomously to …
cancer outcomes is controversial. Although metformin can act on cells autonomously to …
Structural basis of organic cation transporter-3 inhibition
Organic cation transporters (OCTs) facilitate the translocation of catecholamines, drugs and
xenobiotics across the plasma membrane in various tissues throughout the human body …
xenobiotics across the plasma membrane in various tissues throughout the human body …
Metabolic action of metformin
I Szymczak-Pajor, S Wenclewska, A Śliwińska - Pharmaceuticals, 2022 - mdpi.com
Metformin, a cheap and safe biguanide derivative, due to its ability to influence metabolism,
is widely used as a first-line drug for type 2 diabetes (T2DM) treatment. Therefore, the aim of …
is widely used as a first-line drug for type 2 diabetes (T2DM) treatment. Therefore, the aim of …
The role of histamine in the pathophysiology of asthma and the clinical efficacy of antihistamines in asthma therapy
K Yamauchi, M Ogasawara - International journal of molecular sciences, 2019 - mdpi.com
Mast cells play a critical role in the pathogenesis of allergic asthma. Histamine is a central
mediator released from mast cells through allergic reactions. Histamine plays a role in …
mediator released from mast cells through allergic reactions. Histamine plays a role in …
Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells
Metformin, a first line medication for type II diabetes, initially entered the spotlight as a
promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk …
promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk …
Genetics insights in the relationship between type 2 diabetes and coronary heart disease
MO Goodarzi, JI Rotter - Circulation research, 2020 - Am Heart Assoc
Diabetes mellitus is a major risk factor for coronary heart disease (CHD). The major form of
diabetes mellitus is type 2 diabetes mellitus (T2D), which is thus largely responsible for the …
diabetes mellitus is type 2 diabetes mellitus (T2D), which is thus largely responsible for the …
Transporters involved in metformin pharmacokinetics and treatment response
Metformin, widely used as first-line treatment for type 2 diabetes, exists primarily as a
hydrophilic cation at physiological pHs. As such, membrane transporters play a substantial …
hydrophilic cation at physiological pHs. As such, membrane transporters play a substantial …