Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles

DC Luther, R Huang, T Jeon, X Zhang, YW Lee… - Advanced drug delivery …, 2020 - Elsevier
Inorganic nanoparticles provide multipurpose platforms for a broad range of delivery
applications. Intrinsic nanoscopic properties provide access to unique magnetic and optical …

Rational design of nanocarriers for intracellular protein delivery

X Qin, C Yu, J Wei, L Li, C Zhang, Q Wu… - Advanced …, 2019 - Wiley Online Library
Protein/antibody therapeutics have exhibited the advantages of high specificity and activity
even at an extremely low concentration compared to small molecule drugs. However, they …

Bioinspired nanotopographical design of drug delivery systems

JA Finbloom, C Huynh, X Huang… - Nature Reviews …, 2023 - nature.com
Effective drug delivery is important in the treatment of various biomedical conditions, ranging
from autoimmune disorders to cancer and bacterial infections. Nanostructured systems can …

Mesoporous silica nanoparticles for protein protection and delivery

C Xu, C Lei, C Yu - Frontiers in chemistry, 2019 - frontiersin.org
Therapeutic proteins are widely used in clinic for numerous therapies such as cancer
therapy, immune therapy, diabetes management and infectious diseases control. The low …

Evaluation of mesoporous silica nanoparticles for oral drug delivery–current status and perspective of MSNs drug carriers

J Florek, R Caillard, F Kleitz - Nanoscale, 2017 - pubs.rsc.org
The oral pathway is considered as the most common method for drug administration,
although many drugs, especially the highly pH-and/or enzymatic biodegradable peptide …

Metal species–encapsulated mesoporous silica nanoparticles: current advancements and latest breakthroughs

RK Kankala, H Zhang, CG Liu… - Advanced Functional …, 2019 - Wiley Online Library
Despite their advantageous morphological attributes and attractive physicochemical
properties, mesoporous silica nanoparticles (MSNs) are merely supported as carriers or …

Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

F Scaletti, J Hardie, YW Lee, DC Luther… - Chemical Society …, 2018 - pubs.rsc.org
The delivery of proteins into cells is a potential game changer for a wide array of therapeutic
purposes, including cancer therapy, immunomodulation and treatment of inherited diseases …

[HTML][HTML] Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

V Francia, D Montizaan… - Beilstein journal of …, 2020 - beilstein-journals.org
Nano-sized materials have great potential as drug carriers for nanomedicine applications.
Thanks to their size, they can exploit the cellular machinery to enter cells and be trafficked …

[HTML][HTML] Supposedly identical microplastic particles substantially differ in their material properties influencing particle-cell interactions and cellular responses

A Ramsperger, J Jasinski, M Völkl, T Witzmann… - Journal of Hazardous …, 2022 - Elsevier
Microplastics and its putative adverse effects on environmental and human health
increasingly gain scientific and public attention. Systematic studies on the effects of …

Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules

MM Abeer, P Rewatkar, Z Qu, M Talekar, F Kleitz… - Journal of Controlled …, 2020 - Elsevier
Oral ingestion remains as the most convenient route of administration for the application of
pharmaceuticals since it is non-invasive and does not require trained personnel to …