Although cisplatin and its analogues have been widely utilized as anticancer metallodrugs
in clinics, their serious side effects and damage to normal tissues cannot be avoided …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of
the metal, its oxidation state, the types and number of coordinated ligands and the …

Cancer can be defined as an irregular functioning of the cell cycle that results in a
progressive loss of cell differentiation and uncontrolled cell growth. Moreover, despite …

The application of metal compounds in the medical field dates back to the XVI century with
some isolated reports about the therapeutic importance of metals and their compounds in …

A series of metal complexes of Co (II), Zn (II), and Cu (II) of purine base Schiff base ligand L
1 6, 6′-((1E, 1′ E)-((7H-purine-2, 6-diyl) bis (azanylylidene)) bis (methanylylidene)) bis (2 …

Guanine‐rich nucleic acid sequences able to form four‐stranded structures (G‐
quadruplexes, G4) play key cellular regulatory roles and are considered as promising drug …

Two G-quadruplex ligands [Pt (La)(DMSO) Cl](Pt 1) and [Pt (Lb)(DMSO) Cl](Pt 2) have been
synthesized and fully characterized. The two complexes are more selective for SK-OV …

This article provides a comprehensive review of palladium compounds that have been
evaluated for anticancer activity in vivo or in vitro from the era of discovery of cisplatin up to …

Designing ligands targeting G-quadruplex nucleic acid structures and affecting cellular
processes is complicated because there are multiple target sequences and some are …