An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …

Many epithelial tumors grow in the vicinity of or metastasize to adipose tissue. As tumors
develop, crosstalk between adipose tissue and cancer cells leads to changes in adipocyte …

The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …

The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

Creatine kinases (CKs) provide local ATP production in periods of elevated energetic
demand, such as during rapid anabolism and growth. Thus, creatine energetics has …

Perfluorooctane sulfonate (PFOS) has been reported to induce hepatotoxicity in wildlife and
humans. Novel PFOS alternatives have been widely used following restrictions on PFOS …

Clear cell renal cell carcinoma (ccRCC) preferentially invades into perinephric adipose
tissue (PAT), a process associated with poor prognosis. However, the detailed mechanisms …

Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of
cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work …