Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …

Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …

An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

Cancer cells rewire their metabolism to survive during cancer progression. In this context,
tumour metabolic heterogeneity arises and develops in response to diverse environmental …

Many epithelial tumors grow in the vicinity of or metastasize to adipose tissue. As tumors
develop, crosstalk between adipose tissue and cancer cells leads to changes in adipocyte …

The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

Creatine kinases (CKs) provide local ATP production in periods of elevated energetic
demand, such as during rapid anabolism and growth. Thus, creatine energetics has …

Obesity-related cancers account for 40% of the cancer cases observed in the USA and
obesity is overtaking smoking as the most widespread modifiable risk factor for …

Perfluorooctane sulfonate (PFOS) has been reported to induce hepatotoxicity in wildlife and
humans. Novel PFOS alternatives have been widely used following restrictions on PFOS …