Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …

This report provides a review of early and late effects of radiation in normal tissues and
organs with respect to radiation protection. It was instigated following a recommendation in …

Continued improvements in cancer therapies have increased the number of long-term
cancer survivors. Radiation therapy remains one of the primary treatment modalities with …

Abstract Each year, approximately 200,000 patients in the United States will receive partial-
or whole-brain irradiation for the treatment of primary or metastatic brain cancer. Early and …

The incidence of metastasis to the brain is apparently rising in cancer patients and threatens
to limit the gains that have been made by new systemic treatments. The brain is considered …

Approximately 100 000 patients per year in the United States with primary and metastatic
brain tumor survive long enough (> 6 months) to develop radiation-induced brain injury …

Angiotensin II receptor blockers (ARBs, collectively called sartans) are widely used
compounds therapeutically effective in cardiovascular disorders, renal disease, the …

Radiation therapy is the most effective non-surgical treatment of primary brain tumors and
metastases. Preclinical studies have provided valuable insights into pathogenesis of …

The effects of brain AngII (angiotensin II) depend on AT1 receptor (AngII type 1 receptor)
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …