Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

[HTML][HTML] Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies

H Lin, Y Yu, L Zhu, N Lai, L Zhang, Y Guo, X Lin… - Redox Biology, 2023 - Elsevier
Hydrogen sulfide (H 2 S) is an important signaling molecule in colorectal cancer (CRC). It is
produced in the colon by the catalytic synthesis of the colonocytes' enzymatic systems and …

A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

H Ding, J Wei, L Fang, L Feng, S Gai… - Advanced Functional …, 2024 - Wiley Online Library
Hydrogen sulfide (H2S) is being progressively integrated as an emerging inhibitor of the
electron transport chain in energy interference‐based tumor therapy. However, metabolic …

[HTML][HTML] Emerging roles of cystathionine β-synthase in various forms of cancer

K Ascenção, C Szabo - Redox biology, 2022 - Elsevier
The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …

Hydrogen sulfide biology and its role in cancer

S Khattak, MA Rauf, NH Khan, QQ Zhang, HJ Chen… - Molecules, 2022 - mdpi.com
Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian
tissues. It plays a very critical role in many pathophysiological processes in the body. It can …

H2S Donors and Their Use in Medicinal Chemistry

E Magli, E Perissutti, V Santagada, G Caliendo… - Biomolecules, 2021 - mdpi.com
Hydrogen sulfide (H2S) is a ubiquitous gaseous signaling molecule that has an important
role in many physiological and pathological processes in mammalian tissues, with the same …

The hidden role of hydrogen sulfide metabolism in cancer

RH Wang, YH Chu, KT Lin - International Journal of Molecular Sciences, 2021 - mdpi.com
Hydrogen Sulfide (H2S), an endogenously produced gasotransmitter, is involved in various
important physiological and disease conditions, including vasodilation, stimulation of …

Exploring gut microbial metabolites as key players in inhibition of cancer progression: mechanisms and therapeutic implications

T Yin, X Zhang, Y **ong, B Li, D Guo, Z Sha, X Lin… - Microbiological …, 2024 - Elsevier
The gut microbiota plays a critical role in numerous biochemical processes essential for
human health, such as metabolic regulation and immune system modulation. An increasing …

Chemistry of Hydrogen Sulfide—Pathological and Physiological Functions in Mammalian Cells

CMC Andrés, JM Pérez de la Lastra, C Andrés Juan… - Cells, 2023 - mdpi.com
Hydrogen sulfide (H2S) was recognized as a gaseous signaling molecule, similar to nitric
oxide (-NO) and carbon monoxide (CO). The aim of this review is to provide an overview of …

Co-assembled Nanocarriers of De Novo Thiol-Activated Hydrogen Sulfide Donors with an RGDFF Pentapeptide for Targeted Therapy of Non-Small-Cell Lung Cancer

H Chen, X Guan, Q Liu, L Yang, J Guo… - … Applied Materials & …, 2022 - ACS Publications
Hydrogen sulfide releasing agents (or H2S donors) have been recognized gasotransmitters
with potent cytoprotective and anticancer properties. However, the clinical application of …