Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

The transverse asymmetry (sidedness) of phospholipids in plasma membrane bilayers is
well characterized, distinctive, actively maintained and functionally important. In contrast …

Cells employ regulated transport mechanisms to ensure that their plasma membranes (PMs)
are optimally supplied with cholesterol derived from uptake of low-density lipoproteins (LDL) …

Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the
distribution of cellular cholesterol is associated with numerous diseases, including …

To maintain an asymmetric distribution of ions across membranes, protein pumps displace
ions against their concentration gradient by using chemical energy. Here, we describe a …

Bilayered membranes separate cells from their surroundings and form boundaries between
intracellular organelles and the cytosol. Gated transport of solutes across membranes …

Phospholipids are synthesized primarily within the endoplasmic reticulum and are
subsequently distributed to various subcellular membranes to maintain the unique lipid …

Cholesterol is a quantitatively and biologically significant constituent of all mammalian cell
membrane, including those that comprise the retina. Retinal cholesterol homeostasis entails …

Vesicular traffic and membrane contact sites between organelles enable the exchange of
proteins, lipids, and metabolites. Recruitment of tethers to contact sites between the …

Macrophages are professional phagocytes at the front line of immune defenses against
foreign bodies and microbial pathogens. Various bacteria, which are responsible for deadly …