Singlet molecular oxygen reactions with nucleic acids, lipids, and proteins
Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …
[HTML][HTML] Comparison of the mechanisms of DNA damage following photoexcitation and chemiexcitation
In this review, we compare the mechanisms and consequences of electronic excitation of
DNA via photon absorption or photosensitization, as well as by chemically induced …
DNA via photon absorption or photosensitization, as well as by chemically induced …
Computational Study of Oxidation of Guanine by Singlet Oxygen (1Δg) and Formation of Guanine:Lysine Cross‐Links
Oxidation of guanine in the presence of lysine can lead to guanine–lysine cross‐links. The
ratio of the C4, C5 and C8 crosslinks depends on the manner of oxidation. Type II …
ratio of the C4, C5 and C8 crosslinks depends on the manner of oxidation. Type II …
Singlet O2 Oxidation of the Radical Cation versus the Dehydrogenated Neutral Radical of 9-Methylguanine in a Watson–Crick Base Pair. Consequences of Structural …
MM Moe, T Saito, M Tsai, J Liu - The Journal of Physical Chemistry …, 2022 - ACS Publications
In DNA, guanine is the most susceptible to oxidative damage by exogenously and
endogenously produced electronically excited singlet oxygen (1O2). The reaction …
endogenously produced electronically excited singlet oxygen (1O2). The reaction …
Dynamics and Multiconfiguration Potential Energy Surface for the Singlet O2 Reactions with Radical Cations of Guanine, 9-Methylguanine, 2′-Deoxyguanosine, and …
Y Sun, M Tsai, MM Moe, J Liu - The Journal of Physical Chemistry …, 2021 - ACS Publications
Reactions of electronically excited singlet oxygen (1O2) with the radical cations of guanine
(9HG•+), 9-methylguanine (9MG•+), 2′-deoxyguanosine (dGuo•+), and guanosine (Guo•+) …
(9HG•+), 9-methylguanine (9MG•+), 2′-deoxyguanosine (dGuo•+), and guanosine (Guo•+) …
Singlet O2 Reactions with Radical Cations of 8-Bromoguanine and 8-Bromoguanosine: Guided-Ion Beam Mass Spectrometric Measurements and Theoretical …
J Benny, T Saito, MM Moe, J Liu - The Journal of Physical …, 2021 - ACS Publications
8-Bromoguanosine is generated in vivo as a biomarker for early inflammation. Its formation
and secondary reactions lead to a variety of biological sequelae at inflammation sites, most …
and secondary reactions lead to a variety of biological sequelae at inflammation sites, most …
Deprotonated guanine· cytosine and 9-methylguanine· cytosine base pairs and their “non-statistical” kinetics: a combined guided-ion beam and computational study
W Lu, J Liu - Physical Chemistry Chemical Physics, 2016 - pubs.rsc.org
We report a guided-ion beam mass spectrometric study on collision-induced dissociation
(CID) of deprotonated guanine (G)· cytosine (C) base pairs and their 9-methylguanine (9MG) …
(CID) of deprotonated guanine (G)· cytosine (C) base pairs and their 9-methylguanine (9MG) …
Singlet Oxygen Oxidation of the Radical Cations of 8‐Oxo‐2′‐deoxyguanosine and Its 9‐Methyl Analogue: Dynamics, Potential Energy Surface, and Products …
MM Moe, M Tsai, J Liu - ChemPlusChem, 2021 - Wiley Online Library
Oxo‐2′‐deoxyguanosine (OG) is the most common DNA lesion. Notably, OG becomes
more susceptible to oxidative damage than the undamaged nucleoside, forming mutagenic …
more susceptible to oxidative damage than the undamaged nucleoside, forming mutagenic …
pH-Dependent Singlet O2 Oxidation Kinetics of Guanine and 9-Methylguanine: An Online Mass Spectrometry and Spectroscopy Study Combined with Theoretical …
We report a kinetic and mechanistic study on the title reactions, in which 1O2 was generated
by the reaction of H2O2 with Cl2 and bubbled into an aqueous solution of guanine and 9 …
by the reaction of H2O2 with Cl2 and bubbled into an aqueous solution of guanine and 9 …
Computational study of the pH-dependent competition between carbonate and thymine addition to the guanine radical
SP Hebert, HB Schlegel - Chemical Research in Toxicology, 2018 - ACS Publications
When oligonucleotides are oxidized by carbonate radical, thymine and carbonate can add to
guanine radical, yielding either a guanine-thymine cross-link product (G∧ T) or 8-oxo-7, 8 …
guanine radical, yielding either a guanine-thymine cross-link product (G∧ T) or 8-oxo-7, 8 …