Streptomyces are a large and valuable resource of bioactive and complex secondary
metabolites, many of which have important clinical applications. With the advances in high …

Covering: September 1964 to June 2023Bacteria and fungi living in symbiosis with insects
have been studied over the last sixty years and found to be important sources of bioactive …

Streptomyces bacteria are ubiquitous in soils and are well known for producing secondary
metabolites, including antimicrobials. Increasingly, they are being isolated from plant roots …

The presence of secondary metabolite biosynthetic gene clusters (BGCs) makes
actinobacteria well-known producers of diverse metabolites. These ubiquitous microbes are …

Heterologous expression of a three-gene cluster from Streptomyces aurantiacus coding for a
cyclodipeptide synthase, a prenyltransferase, and a methyltransferase led to the elucidation …

In this study, we isolated an endophytic Streptomyces sp. strain, WP-1, from surface-
sterilized barks of Pinus dabeshanensis, an endangered Chinese plant. WP-1 showed …

Fungus-growing termites are engaged in a tripartite mutualism with intestinal microbes and
a monocultivar (Termitomyces sp.) in the fungus garden. The termites are often plagued by …

Streptomyces species are considered to be the most prolific sources of various bioactive
secondary metabolites that are important for antibiotic production. Here, we describe a …

The total synthesis of the potent polyene macrolide antibiotic pentamycin was accomplished
by an expedient strategy involving a highly stereoselective assembly of the polyol segment …

Nine new (1–3, 5–8, 11, and 12; named filipins VI–XIV) and three known (4, 9, and 10) filipin-
type polyene macrolides were isolated from the deep-sea-derived Streptomyces antibioticus …